Mini Brains Uncover Treatment Leads for Lewy Body Dementia

Lewy body dementia (LBD) is a challenging-to-diagnose neurodegenerative disease with symptoms similar to both Parkinson’s and Alzheimer’s diseases, including hallucinations, cognitive issues, and movement disorders. To study LBD’s progression, researchers developed mini brain models from LBD patient stem cells, replicating key disease characteristics seen in human brains. These models helped identify four promising drugs that may inhibit alpha-synuclein buildup, a key protein associated with LBD.