Toxic Protein May Uniquely Affect Brain, Spine, and Muscles in ALS

A recent study reveals that the toxic trimer form of the protein SOD1 affects the brain, spinal cord, and muscle tissues differently in ALS, shedding light on its complex progression. The study found SOD1 trimers bind uniquely to different proteins in each tissue type, potentially impacting cellular communication, structure, and energy production. For instance, SOD1 trimers in neurons affect cellular aging and communication, while in muscle cells, they disrupt metabolic processes.