How a Brain Lipid’s Production Could Impact Dementia

Researchers have discovered how a lipid molecule, BMP, crucial for brain function, is produced, potentially opening new doors for treating neurodegenerative diseases like Alzheimer’s and frontotemporal dementia. Two enzymes, PLD3 and PLD4, were found to catalyze the formation of BMP by changing the molecule’s “handedness,” allowing it to remain stable in lysosomes where other lipids are broken down.